Lesions of mediodorsal thalamic nucleus reverse abnormal firing of the medial prefrontal cortex neurons in parkinsonian rats
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چکیده
منابع مشابه
The prefrontal cortex: Projection area of the thalamic mediodorsal nucleus?
The historical bases of the definitions of the prefrontal cortex are reviewed (cytoarchitecture, electrical unexcitability, afferents from the mediodorsal thalamic nucleus). Evidence is presented that the widely accepted proposal of Rose and Woolsey (1948) to name all cortex prefrontal that is reached by afferents from the mediodorsal nucleus is questionable for three reasons: the diversity of ...
متن کاملCortical projections of the thalamic mediodorsal nucleus in the rat. Definition of the prefrontal cortex.
Deposits of somatopetal tracers, that filled the entire dorsolateral cortex of one hemisphere, labelled only a few cell bodies in the thalamic mediodorsal nucleus (MD). Further experiments served to confirm the existence of strong projections from MD to the mesial and suprarhinal areas of the frontal cortex. Thus, only a very small proportion of the MD neurones in the rat projects outside the c...
متن کاملDistribution of mediodorsal thalamic nucleus afferents originating in the prefrontal association cortex of the dog.
The nediodorsal thalamic nucleus (MD) afferents originating in the prefrontal cortex (PFC) were studied in 14 dogs, using the method of retrograde horseradish peroxidase transport. Injections limited to small areas of MD indicated that projection between MD and PFC shows precise topography and reciprocity. However, the distribution of labeled neurons suggests a division of MD into two main segm...
متن کاملThalamic mediodorsal nucleus and its participation in spatial working memory processes: comparison with the prefrontal cortex
Working memory is a dynamic neural system that includes processes for temporarily maintaining and processing information. Working memory plays a significant role in a variety of cognitive functions, such as thinking, reasoning, decision-making, and language comprehension. Although the prefrontal cortex (PFC) is known to play an important role in working memory, several lines of evidence indicat...
متن کاملThe Study of Apomorphine Effects and Heterogeneity in the Medial Prefrontal Cortex on the Dopaminergic Behaviors of Rats
Objective(s) While the nucleus accumbens and the striatum have received much attention regarding their roles in stereotyped behaviors, the role of the medial prefrontal cortex (mPFC) has not been investigated to the same degree. Few studies have reported the role of the mPFC in dopaminergic induction of locomotor hyperactivity. The mPFC is a heterogeneous area (the anterior cingulated, prelimbi...
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ژورنال
عنوان ژورنال: Neural Regeneration Research
سال: 2019
ISSN: 1673-5374
DOI: 10.4103/1673-5374.255982